From Longman Dictionary of Contemporary Englishfuck up phrasal verb taboo spoken1 fuck somebody ↔ up to make someone very unhappy and confused so that they cannot live normally or have normal relationships → mess somebody upHeroin fucks you up.2 to make a mistake or do something badly → mess upYou really fucked up this time.fuck something ↔ upI’m scared of fucking things up. → fuck→ See Verb table