Oxford Dictionary English sex chromosome nounnoun BrE BrE//ˈseks krəʊməsəʊm// ; NAmE NAmE//ˈseks kroʊməsoʊm// (biology) Genetic engineering Add to my wordlistjump to other results a chromosome that decides the sex of an animal or a plant see also X chromosome, Y chromosome See related entries: Genetic engineeringSee sex chromosome in the Oxford Advanced American DictionaryCheck pronunciation: sex chromosome oxfordlearnersdictionaries.com