the fact of somebody only considering their own interests and of not caring about things that would help other peopleNot all of them were acting out of self-interest.Oxford Collocations Dictionaryadjectiveenlightened,rational,economic,…verb + self-interestbe motivated by,pursue your ownphrasesact in self-interest,act out of self-interest,in your own self-interest,…Seefull entry
See self-interest in the Oxford Learner's Dictionary of Academic EnglishSee self-interest in the Oxford Advanced American Dictionary