Oxford Dictionary English midtown nounnoun BrE BrE//ˈmɪdtaʊn// ; NAmE NAmE//ˈmɪdtaʊn// [uncountable] (North American English) Add to my wordlistjump to other resultsthe part of a city that is between the central business area and the outer parts a house in midtown midtown Manhattan compare downtown, uptownSee midtown in the Oxford Advanced American DictionaryCheck pronunciation: midtown oxfordlearnersdictionaries.com