Oxford Dictionary English mainframe noun noun BrE BrE//ˈmeɪnfreɪm// ; NAmE NAmE//ˈmeɪnfreɪm// (also mainframe computer) Add to my wordlistjump to other results a large powerful computer, usually the centre of a network and shared by many users compare microcomputer, personal computerSee mainframe in the Oxford Advanced American DictionaryCheck pronunciation: mainframe oxfordlearnersdictionaries.com