From Longman Dictionary of Contemporary Englishsomething is upsomething is upspokenPROBLEM if something is up, someone is feeling unhappy because they have problems, or there is something wrong in a situation I could tell by the look on his face that something was up.something is up with Is something up with Julie? She looks really miserable.what’s up? What’s up? Why are you crying? → up
Examples from the Corpus
what’s up?• "Hey Chris, what's up?" "Not much." 