From Longman Dictionary of Contemporary Englishmidtownmid‧town /ˌmɪdˈtaʊn◂/ adjective, adverb American English SGin the area of a city that is quite near the centre but is not the main business area → downtown, uptown —midtown noun [uncountable]
Examples from the Corpus
midtown• a restaurant in midtown ManhattanMidtownMidtown noun American English a central area of a city, especially the part of Manhattan in New York City which is south of Central Park → compare downtown, uptown 