From Longman Dictionary of Contemporary Englishwith every fibre of your beingwith every fibre of your beingliteraryEMOTIONAL if you feel something with every fibre of your being, you feel it very strongly He wanted her with every fibre of his being. → fibre
Examples from the Corpus
with every fibre of your being• What she was sure of, though, was that she wanted him with every fibre of her being.• And in that moment she wished with every fibre of her being that it really was possible for her to stay away. 