Longman Dictionary English From Longman Dictionary of Contemporary EnglishRelated topics: Illness & disabilityLyme diseaseLyme dis‧ease /ˈlaɪm dɪˌziːz/ noun [uncountable] MIa serious illness that is caused by a bite from a tick1(2)Origin Lyme disease (1900-2000) Old Lyme, town in Connecticut, USA, where the disease was first recognized ldoceonline.com